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The FDA restricts GLP-1 agonists (semaglutide, tirzepatide, retatrutide) to prescription status because metabolic pathways, kidney function, thyroid history, and cardiovascular factors must be assessed before initiation

Further investigations are needed to confirm this hypothesis

Ma J, Yang L, Ren J, Yang J

Why menopause changes the weight equation During the menopause transition, declining estrogen, disrupted sleep, increased stress, and shifts in insulin sensitivity can all make weight management harder

For this RCT, we identified a conference abstract that similarly reported a positive effect of exenatide on weight reduction and BMI 146

So far, however, from the data thats been collected, it looks like its very effective, Shafipour told Healthline